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Image Search Results
Journal: Cells
Article Title: Induced Pluripotent Stem Cell-Derived Neural Precursors Improve Memory, Synaptic and Pathological Abnormalities in a Mouse Model of Alzheimer’s Disease
doi: 10.3390/cells10071802
Figure Lengend Snippet: 3xTg-AD mice transplanted with iPSC-NPCs displayed lower levels of ThS-positive amyloid deposits and soluble and insoluble Aβ in brains. ( a – d ) ThS-stained brain slices from 3xTg-AD iPSC-NPCs and PBS-injected mice were analyzed with an epifluorescent microscope. ThS-positive fibrillar deposits was reduced in the hippocampus of 3xTg-AD iPSC-NPCs-injected mice ( a , c ) compared with PBS-injected mice ( b , d ). Scale bar: ( a , b ) 300 μm; ( c , d ) 25 μm. ( e ) The burden of ThS-positive deposits was attenuated in 3xTg-AD iPSC-NPCs mice compared to 3xTg-AD PBS mice (student t -test, ** p < 0.01). ( f ) The quantity of PBS soluble and formic acid (FA) insoluble (aggregated) total Aβ was elevated in 3xTg-AD PBS mice compared to the iPSC-NPCs-injected counterpart as measured by ELISA ( n = 7–8/group) (student t -test, ** p < 0.01; * p < 0.05). Data corresponds to means ± SEM.
Article Snippet: All resulting samples were stored at −80 °C until measured by a
Techniques: Staining, Injection, Microscopy, Enzyme-linked Immunosorbent Assay